Engineering skin microbiomes for thermal regulation
Abstract
The human microbiota, consisting of a vast array of microorganisms, plays a pivotal role in host physiology and immunity. Among these microbes, Cutibacterium acnes (C. acnes) which is a human commensal microbe, has garnered attention for its potential in thermogenic processes. The human microbial population is estimated to be 3.8x10^13 cells per person, and the gut microbiota could contribute substantially to the generation of heat. However, the role of skin microbiota, particularly C. acnes, in thermogenesis remains underexplored. This project examines C. acnes# genetic potential, including its low turnover rate and access to energetic substrates such as triglycerides and squalene on the skin, making it an attractive candidate for microbe-mediated thermogenesis. Recent advancements in synthetic biology have allowed researchers to engineer C. acnes for enhanced thermogenic capabilities, offering promising avenues for biomedical engineering and environmental adaptation. This interdisciplinary approach holds implications for diverse applications, from combating hypothermia in extreme environments to optimizing thermal comfort in controlled settings. By elucidating the mechanisms underlying microbe-mediated thermogenesis and harnessing the metabolic potential of skin microbiota, this research will provide new technologies addressing temperature-related challenges in human health and environmental adaptation, including challenges in the US Navy divers.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Nov 09, 2024
- Source ID
- N000142412723
Entities
People
- Tae Seok Moon
Organizations
- J. Craig Venter Institute
- Office of Naval Research
- United States Navy