Translational Injury Model System for identifying Neuroimaging and Neural Signaling-based Biomarkers for Early Detection and mitigation of mild Traumatic Brain Injury
Abstract
Approved for public release. Timely mitigation of traumatic brain injury (TBI) for warfighters in the field has greatly suffered from the inability to perform immediate diagnostics with clinical-grade modalities including electroencephalography (EEG) and whole brain magnetic resonance imaging (MRI). Over the past several years with support from the Office of Naval of Research (ONR), the PANTHER program has performed pioneering research for identifying the effect of diverse forms of brain injuries at the cellular, sub-cellular and tissue level scales, and is now moving towards complete volumetric optical reconstruction of physical and biological injury at higher than ever frame rates. This work is now ripe to advance towards the preclinical and clinical regimes to help leverage smart helmets and other real time diagnostics for predicting harmful effects early and select proper interventions to improve long term prognosis. This project aims to bridge the gap between cellular scale investigation and clinical diagnostics by deploying an MRI-compatible rotational acceleration brain injury device and use advanced neuroimaging and electrophysiological tools in translational minipig animal models to open new avenues for clinical detection and mitigation of structural and functional brain abnormalities post injury.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Nov 26, 2024
- Source ID
- N000142512000
Entities
People
- Aviad Hai
Organizations
- Office of Naval Research
- United States Navy
- University of Wisconsin System