NICOP - MODULATION OF BRAIN FUNCTIONS
Abstract
The overall aim of this project is to investigate the effects of transcranial direct current stimulation (tDCS), a non-invasive brain stimulation (NIBS) technique, on brain plasticity. In particular, we plan to apply tDCS in vivo on different brain areas and evaluate the impact of stimulation on motor or cognitive functions. To pursue these goals we will use animal models that are invaluable tools to identify changes in higher brain functions and to investigate the underlying mechanisms. Different methodological approaches will be employed to study the effect of tDCS on plasticity, including electrophysiological, behavioral and molecular tests. To assess the duration of tDCS effects, experiments will be performed either few hours after stimulation or 7-14 days later. Because of the lack of knowledge on basic mechanisms underlying tDCS effects, the identification of the molecular determinants of tDCS effects on brain plasticity will be the most innovative goal of the proposed research. Gaining such knowledge will allow a more conscious transferability of tDCS application from basic research to real-life and therapeutic intervention as well as to risky contexts. Warfighters would greatly benefit of a safe and NIBS tool able to potentiate their motor functions such as their attention, impulsivity, risk-taking, working memory and planning abilities. Beneficial effects of tDCS may also include the improvement of synaptic plasticity deficits in dorso-lateral prefrontal cortex typically reported in post-traumatic depression events. Results obtained will be presented at ONR Headquarters and international conferences (e.g, Annual meeting of the Society for Neuroscience). They will be published as original articles on international journals (e.g., J. Neurosci., Brain Stimulation, J. Physiol., J Neurophysiol.) and posted on websites.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Aug 12, 2016
- Source ID
- N629091512002
Entities
People
- Claudio Grassi
Organizations
- Office of Naval Research
- United States Navy