Fish-Skin Acellular Dermal Matrix (ADM) in the Acute Care of Severely Injured Limbs (lab work)
Abstract
Kerecis believes that a wound cover containing Kerecis Omega3 ADM will be suitable for all types of trauma wounds. In the first 36 hours after injury, the material’s mode of action typically includes hemostasis, infection control, down-regulation of MMPs and potentially other biological activity such as reduced inflammation, soothing and pain reduction.Under the ACCSIL specification, Kerecis Omega3 ADM would be suitable as the main component of the Internal Bioactive Coating (IBC). A pilot project is proposed to confirm the applicability of the Kerecis technology for this purpose.Kerecis team members possess proven track record in the development of wound dressings, skin interface applications and prosthetics. This track record provides the team with excellent background - not only for the IBC but also for the Conformal Cover (CC) that will deliver the IBC to the wound bed, fluid regulate the wound and protect under transport. The team is up to date with the latest developments in material sciences, such as with intelligent textiles and other materials have the capability to form, stretch and remember shapes. This will be beneficial when developing the CC.Kerecis proposes a pilot project with the ONR to collaboratively build on the excellent clinical results of the Kerecis ADM material and on the competencies of the Kerecis team. The pilot project will be the first step in equipping medics with a new, important product for use on the battlefield and during medi-vac. The fish-skin ADM, in combination with the skin interface and prosthetic competence of the Kerecis organization, presents a major opportunity to develop new types of trauma-wound-treatment products for use in the first 36 hours after trauma occurs.The pilot project will focus on demonstrating the use of Kerecis Omega3 matrix via in-vitro experiments as an infection controller and as a hemostatic agent with the primary object of demonstrate that the Kerecis technology can be used in acute care and transport.In case the pilot project will be deemed successful by the ONR, a more extensive development project for manufacturing a ready wound-treatment product will be proposed.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Feb 03, 2017
- Source ID
- N62909151N084
Entities
People
- Baldur Baldursson
Organizations
- Office of Naval Research
- United States Navy