NICOP - Enabling skin microbiome as a portable genetic extension to the host
Abstract
I will use natural skin microbes as a specialized, customizable, and reversible genetic extension of the host.First, I will develop a technology to deliver genetic circuits to the skin microbiome using refactored naturalphages. Second, I will assemble 2 genetic circuits to monitor real-time host adrenaline production, andaccumulation of multiple consequences of radiation damage. Real-time adrenaline sensory componentstransduce the sensed input into an optical signal which can be easily recorded using systems such aswearables. Consequences of radiation damage such as protein damage or DNA damage are molecularlyrecorded using the cas1-cas2 system. Finally, circuits will be characterized in vitro, and in vivo using ahairless mice model (7). Stability and performance will be characterized over time.Biological sensing in the skin enables precise and sensitive measurement of potential threads. The platformwill be constructed following a modular strategy. Future development may include multiplexable sensing,different channels of signal transduction, and multiple responses to the sensed signals.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Sep 19, 2018
- Source ID
- N629091812155
Entities
People
- Marc Gell
Organizations
- Office of Naval Research
- Pompeu Fabra University
- United States Navy