Production and characterization of microcontact printed substrates with potential for bacteria repellency and generation of mechano-bactericidal nanostructured surfaces
Abstract
Keeping surfaces bacteria-free to avoid the spread of disease is of interest in hospital settings and bathrooms in civil and militarKeeping surfaces bacteria-free to avoid the spread of disease is of interest in hospitalsettings and bathrooms in civil and military facilities. Current approaches for surface decontamination are usually active treatments, some of which are expensive or toxic, such as chemical (e.g. antibacterial agents), physical (e.g. UV/ozone) or thermal (steam) protocols. We propose the experimental inveschas chemical (e.g. antibacterial agents), physical (e.g. tigation of multiple passive strategies to makesurfaces intrinsically sterile by preventing bacteria adhesion (through water repellency)and/or killing bacteria upon contact with nanostructures on the surface. The first goal is making hydrophobic surfaces by meency)and/or killing bacteria upon contact with nanostructures on the surface. The first goal ismaking hydrophobic surfaces by meanans of microcontact printed monolayers with patterns designed to maximize surface roughness. Wenzel and Cassie-Baxter models are tos of microcontact printed monolayers with patternsdesigned to maximize surface roughness. Wenzel and Cassie-Baxter models are to be be tested at the nanoscale regime, and the hypothesis of reduced bacteria adhesion using nanoscale features is to be validated. Ttested at the nanoscale regime, and the hypothesis of reduced bacteria adhesion usingnanoscale features is to be validated. The second goal includes two approaches ofmechano-bactericidal action, one by means of nanopillars on alumina and on elastomersand a seche second goal includes two approaches of mechano-bactericidal action, one by means of nanopillars on alumina and on elastomersand a second approach by means of ZnO needle-like nanocrystals with morphologies conducive to mechanical damage of bacteria. All surfacond approach by means of ZnO needle-like nanocrystals with morphologiesconducive to mechanical damage of bacteria. All surfaces woues would be characterized by surface sensitive techniques and bactericidal action assessed by standard microbiology techniques.Theld be characterized by surfacesensitive techniques and bactericidal action assessed by standard microbiology techniques.The third goal of the project intends to validate a new synthesis method for graphenequantum dots and their application for bacterial imagin third goal of the project intends to validate a new synthesis method for graphene quantum dots and their application for bacterial imaging, which is useful to visualize E. coli used in tests for goals one and two. Development of these surface modification technog, which is useful to visualize E. coliused in tests for goals one and two. Development of these surface modification technologieslogies could quickly find practical applications as a sterilization technique (or work synergistically with current techniques), and the basic science involved in the development and characterization of nanoscale bactericidal surfaces is of interest to the surfacesic science involved in the development andcharacterization of nanoscale bactericidal surfaces is of interest to the surface scienc science community. Hence, we expect at the end of the project to have at least a bacteria-repellingor bacteria-killing surface andecommunity. Hence, we expect at the end of the project to have at least a bacteria-repellingor bacteria-killing surface and delive deliver at least one scientific paper discussing the technology and science behind our approach(es).r at least one scientific paper discussing the technologyand science behind our approach(es).
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- May 08, 2020
- Source ID
- N629092012031
Entities
People
- Sergio Paniagua Barrantes
Organizations
- National High Technology Center
- Office of Naval Research
- United States Navy