A New Generation of Chassis to Gene Expression: from Yucatán to Synthetic Biology
Abstract
Synthetic Biology (SB) uses the result of evolution and through the design of genetic parts creates novel phenotypes. Today the SB iSynthetic Biology (SB) uses the result of evolution and through the design of genetic partscreates novel phenotypes. Today the SB is built on a very small set of domesticated laboratory organisms and new chassis are required to expand SB capabilities. The purposes built on a very small set of domesticated laboratoryorganisms and new chassis are required to expand SB capabilities. The purpose of this research is a systematic search using omics prospecting to identify bacterial organisms in the coastal areas of Yucatan of thisresearch is a systematic search using omics prospecting to identify bacterial organismsin the coastal areas of Yucatan to obtain new chassis to be used in Synthetic Biology for the gene expression of commercial molecules. To achieve the proposed obje to obtain new chassis to be used in Synthetic Biology forthe gene expression of commercial molecules. To achieve the proposed objective will beused next generation sequencing (NGS) tools, bioinformatics analysis, and the design of genetic circuits, which will active will beused next generation sequencing (NGS) tools, bioinformatics analysis, and the design ofgenetic circuits, which will allow us to identify candidate bacteria to be used as new chassis in Synthetic Biology for the expression of rhamnolipids, which arellow us to identify candidate bacteria to be used as new chassisin Synthetic Biology for the expression of rhamnolipids, which are non-ribosomal peptidesthat have a very wide use, from the oil industry to the decontamination applications. This research is relate non-ribosomal peptidesthat have a very wide use, from the oil industry to the decontamination applications. Thisresearch is relatd to priorities identified in the Naval Research and Development Framework, which are developed within the Synthetic Biology for Naved to priorities identified in the Naval Research and Development Framework,which are developed within the Synthetic Biology for Naal Applications program inthe Warfighter Supremacy portfolio of ONR. As with the research carried out in the Center for Biomoleculaval Applications program inthe Warfighter Supremacy portfolio of ONR. As with the research carried out in the Centerfor Biomolecular Science and Engineering (CBMSE) at the Naval Research Laboratorywithin thematic area of Fundamental Biology: Bacterial Systems ar Science and Engineering (CBMSE) at the Naval Research Laboratory within thematic area of Fundamental Biology: Bacterial Systems and Synthetic Biology. The results of our research will be reflected in the publication of 1-2 research articles, as well as the constnd Synthetic Biology. Theresults of our research will be reflected in the publication of 1-2 research articles, as well asthe consruction of a strain producing rhamnolipids using a new chassis of synthetic biology.truction of a strain producing rhamnolipids using a new chassis of synthetic biology.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- May 08, 2020
- Source ID
- N629092012032
Entities
People
- Mario Martínez Nunez
Organizations
- National Autonomous University of Mexico
- Office of Naval Research
- United States Navy