Aptamer-based stress sensor as novel diagnostic
Abstract
Synthetic biology is providing innovative solutions for challenges in medicine through the design of new biological components. ExciSynthetic biology is providing innovative solutions for challenges in medicine through the design of newbiological components. Exciting applications are synthetic biological sensing devices for the detection of small molecules that become important in many areasting applications are synthetic biological sensing devices for the detection ofsmall molecules that become important in many areas of life. It ranges from monitoring individual patient drug or hormone levels, to food or environmental contaminant. In every case, of life. It ranges from monitoring individual patientdrug or hormone levels, to food or environmental contaminant. In every case, more favorable outcomes are achieved when tests are performed on-site or at point-of-care as immediate action can be taken. For more favorable outcomes areachieved when tests are performed on-site or at point-of-care as immediate action can be taken. For such applications a sensor system which is highly stable under a broad range of working conditions is necessary.Nucleic acid aptam suchapplications a sensor system which is highly stable under a broad range of working conditions is necessary.Nucleic acid aptamers are short DNA or RNA single strands, which can fold into a highly complex three dimensional structure that can bind different taers are short DNA or RNA single strands, which can fold into a highly complex threedimensionalstructure that can bind different targets. The project will use aptamers to develop a biosensor thatcan efficiently and quickly measure a persons stress level. The prorgets. The project will use aptamers to develop a biosensor that can efficiently and quickly measure a persons stress level. The proposal aims for the following three mainobjectives: 1) Selection of aptamers that can recognize the respective target molecules wiposal aims for the following three mainobjectives: 1) Selection of aptamers that can recognize the respective target molecules with high affinity andspecificity 2) Detailed characterization of the selected aptamers and 3) Further development of these aptamerintth high affinity and specificity 2) Detailed characterization of the selected aptamers and 3) Further development of these aptamer into aptamer-based biosensors.o aptamer-based biosensors.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jun 25, 2021
- Source ID
- N629092012035
Entities
People
- Beatrix Suess
Organizations
- Office of Naval Research
- Technical University of Darmstadt
- United States Navy