Development of three-dimensional scaffolds for regenerative medicine of skin and bone
Abstract
The purpose of this research is to develop medical devices for the treatment ofwounds in skin and bones by bioprinting. Different bioinks will be made to bioprintthese organs, forming the bioconstructs. Tests with cells will be performed. Molecules(immunomodulatory protein factors) will be detected and quantified from the culturemedium and from the secretions of three-dimensional cultures of cells seeded onscaffolds. The culture medium (conditioned medium) will be also used to assess theeffect of these secretomes on transcription of extracellular matrix proteins involved inwound healing expressed by three-dimensional cultures of artificial skin connectivetissue and bone treated or not with the conditioned media. It is known that The MarineCorps of the US are prone to suffer lesions of the skin and bones, so the in vitroevaluation of specific mechanisms that mediate the bioactivity of scaffolds/cells/cellularmicroenvironment will help in the compression of in vivo wound healing and in thedesign of medical devices that help improve the treatment of human beings sufferingfrom these injuries. The results obtained will be presented in conferences, websites,journal articles and in the development of medical devices.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Aug 05, 2021
- Source ID
- N629092112026
Entities
People
- Patricia Pranke
Organizations
- Fundação de Apoio à Universidade do Rio Grande
- Office of Naval Research
- United States Navy