Vagal Neuromodulation for the Treatment of Inflammatory Bowel Disease
Abstract
The Recipient will (i) define the functional neural pathways by which vagal nerve stimulation (VNS) ameliorates inflammation of the gut; (ii) devise optimal closed-loop neuromodulation treatments for inflammatory bowel disease (IBD); (iii) determine correlations between animal model and human circuits: (iv) develop stimulating and recording electrodes and wirelessly controlled stimulation and recording suited for animal proof-of-principle experiments; (v) develop and test the validity of mathematical models of the control circuitry; and (vi) conduct clinical tests of safety and effectiveness of optimized stimulation in patients. The outcomes will be detailed functional and anatomical maps of the nerve pathways through which vagal nerve stimulation reduces the severity of IBD in rat and human, the identification of appropriate neural interfaces and biosensors, the demonstration of safety and efficacy of VNS, and a first-in-human clinical trial of the effectiveness of selective stimulation of vagal pathways to the inflamed bowel.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jan 06, 2022
- Source ID
- N660011524060
Entities
People
- John B. Furness
Organizations
- Defense Advanced Research Projects Agency
- Florey Institute of Neuroscience and Mental Health
- Naval Information Warfare Center Pacific