Fibrosis, Inflammation, Revascularization, and Migration Modulation for Muscle Regeneration
Abstract
Spontaneous muscle regeneration is impaired in individuals suffering volumetric muscle loss (VML) larger than 10% tissue mass caused by trauma or dystrophy. A number of challenges await to be overcome: (1) enhancing muscle progenitor cell migration to the wound site; (2) suppressing inflammatory responses detrimental to healing; (3) preventing fibrosis and scar tissue; and (4) promoting revascularization. To address these challenges all at once, we propose an im-plantable tissue construct, coined with the acronym “FIRM”, to modulate Fibrosis, Inflammation, Revascularization, and Migration.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Apr 19, 2023
- Source ID
- N660012314012
Entities
People
- Yun Chen
Organizations
- Defense Advanced Research Projects Agency
- Johns Hopkins University
- Naval Information Warfare Center Pacific