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Abstract
TEST123: Recent evidence suggest that lipids circulating in blood are derived in part from the central nervous system, with levels of specific lipid species changing in subjects suffering from a variety of neurodegenerative conditions. Of specific relevance to this proposal, recent studies have shown changes in blood lipids in patients with mild cognitive impairments associated with Alzheimer’s disease or Parkinsonism (PD) or in psychiatric conditions such as major depression (with unique lipid profiles for each condition). Moreover, longitudinal studies have shown that plasma lipid profiles could be prognostic indicators for later neurocognitive declines. These results suggest that mild traumatic brain injury (mTBI), a condition in which localized neuroinflammation and loss of neural tissues occurs, will also be accompanied by changes in circulating lipids originating from injured or degenerating neural tissues.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Mar 02, 2020
- Source ID
- TEST123123123
Entities
People
- Test Dtic
Organizations
- Defense Technical Information Center
- United States Department of Defense