Schwannomatosis-Associated Schwannomas: Molecular Profiling of Laser-Microdissected Tumor Cells with Distinctive INI1 Protein Expression
Abstract
Germline inactivating mutations of the SMARCB1 gene on chromosome 22 have been identified in about 30% of schwannomatosis families, and in 7%-10% of patients without affected relatives. However, it is not clear, yet, how SMARCB1 contributes to the tumor development in schwannomatosis patients. This project focuses on the molecular analysis of schwannomas of well-characterized schwannomatosis patients, with the aim to discover the peculiar tumorigenic mechanism of this kind of tumors. The discovery of the molecular mechanism of tumorigenesis in schwannomatosis patients will contribute to the development of new medical approaches to improve clinical management and quality of life of affected patients.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Apr 04, 2016
- Source ID
- W81XWH1510164
Entities
People
- Laura Papi
Organizations
- United States Army
- University of Florence