The Role of Cyclin D1 in the Chemoresistance of Mantle Cell Lymphoma
Abstract
Cancer cells frequently acquire mechanisms to minimize genetic damage caused by anticancer drugs, making them resistant to treatments and become deadly. Our goal is to understand how cancer cells guard against DNA damage and exploit this knowledge for treatment intervention. We have discovered a novel function of a cancer-causing protein in maintaining DNA stability of mantle cell lymphoma (MCL), an aggressive and incurable form of blood cancers. The proposed research aims to unlock this protein s new function, which has potential to facilitate development of more effective therapeutic strategies in MCL. The Principal Investigator s (PI s) career goal is to establish an independent research program in the area of blood cancers. The award will provide a crucial resource needed to generate solid preliminary data for publication and obtaining funding, which are critical to advance the PI s early-stage career and to establish his new field at the forefront of cancer research. The PI s research has strongly focused on the mechanisms underlying chemoresistance of cancer cells and employ new knowledge to overcome such barriers in cancer treatment. An individualized career development plan has been developed and tailored for this specific research focus, taking advantage of available resources and support from institutional research environment. Several concrete steps in the career planning would increase the chances of attaining the PI s career goals. Results from the proposed research are expected to benefit MCL patients, who often have poor prognosis related to marked resistance to therapy. Successful completion of this project should yield new information underlying MCL resistance to chemotherapeutic agents and help to develop novel pharmacologic strategies to overcome resistance in MCL and other cancers driven by similar mechanisms. Exposure to chemical and biological agents increases the risk of developing lymphoma and many other blood cancers. Mantle cell lymphoma is more common in older men and thus Vietnam War Veterans are the most at risk of developing this cancer. The proposed research will help advancing treatments that will have a positive impact on this population and potentially on other active duty Service members in the future.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Apr 04, 2016
- Source ID
- W81XWH1510297
Entities
People
- Vu Ngo
Organizations
- Beckman Research Institute of City of Hope
- United States Army