Role of HMGB1 in Transfusion-Mediated Lung Inflammation
Abstract
Epidemiological studies have shown that red blood cell (RBC) transfusions are associated with increased morbidity and mortality and the development of Acute Respiratory Distress Syndrome (ARDS; life-threatening respiratory failure) in susceptible populations, particularly trauma patients. The etiology underlying this association remains uncertain. We have recently found that banked RBCs can incite a form of cell death in lung cells. This form of cell death called necroptosis leads to the release of inflammatory proteins that can alter the immune response. We have also found that the inflammatory protein High Mobility Group Box 1 (HMGB1) is released following RBC-induced death of lung cells. The main goal of this study is to define the mechanisms by which RBC transfusions increase the risk of ARDS development in the critically ill. Specifically, we will examine how HMGB1 that is released following transfusion alters the inflammatory response. Completion of these studies may lead to novel therapies to prevent the development of ARDS in transfusion recipients, including trauma patients and wounded Soldiers.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Mar 29, 2016
- Source ID
- W81XWH1510363
Entities
People
- Nilam Mangalmurti
Organizations
- United States Army
- University of Pennsylvania