Characterization of Ran Binding Protein (RANBP6) as Candidate Tumor Suppressor
Abstract
The proposed work will support the predoctoral studies of Ms. Hsieh whose primary research interest is in genetic cancer research (Fiscal Year 2015 [FY15] Peer Reviewed Cancer Research Program [PRCRP] Topic Areas). She has identified a new member (RANBP6) of a well-studied growth factor signaling pathway (EGFR), has established new mechanistic insights related to the intracellular transport of key regulatory proteins (RanGTPase), and now will determine the role of this protein in cancer. The researcher development plan supports Ms. Hsieh in attaining these goals by: (i) acquisition of the scientific skills in the research project through close collaborations with outstanding physician-scientists in the Memorial Sloan Kettering Cancer Center (MSKCC) and Weill Cornell Medical College; and (ii) improvement of scientific knowledge in the field of cancer through participation in weekly cancer-related seminars hosted by the MSKCC Human Oncology and Pathogenesis Program (Chair; Charles Sawyers) and by the MSK Cancer Biology and Genetics Program (Chair; Scott Lowe). The Principal Investigator s mentor, Dr. Mellinghoff, will also fully support the proposed research by weekly one-on-one discussions and through laboratory meetings. The proposed work applies to several cancer types afflicting active duty Service members and Veterans. These include cancers with abnormal growth factor signaling, including colorectal cancer, melanoma, stomach cancer, neuroblastoma, kidney cancer, and pancreatic cancer, all of which are listed in FY15 PRCRP Topic Areas. The identification of crucial RanBP6 target proteins will allow us to link this tumor suppressor to possible new drug targets within 5 years. By characterizing a gene that is often lost in cancer together with its neighboring gene, our work will provide insights into the larger question why cancer cells often prefer loss of larger genomic areas containing multiple genes over the focal loss of only a single gene.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jan 31, 2017
- Source ID
- W81XWH1610193
Entities
People
- Wan-ying Hsieh
Organizations
- United States Army
- Weill Cornell Medicine