Inhibition of Chondrocyte Hypertrophy of Osteoarthritis by Disruptor Peptide
Abstract
This application is in response to Fiscal Year 2015 Peer Reviewed Medical Research Program Topic Area of "Osteoarthritis." Osteoarthritis is a painful joint disease that most often occurs in weight-bearing joints: the hips, knees, spine, ankles, as well as in the fingers. It is a wear-and-tear disease that results from the breakdown of cartilage at the end of bones. With cartilage damage, opposing bones rub together, causing pain. Osteoarthritis is the most common form of arthritis and is traditionally considered a disease affecting older individuals, with incidence rates increasing with age. However, close to 27 million Americans age 25 and older have osteoarthritis and this disabling condition accounts for 25% of all arthritis-related healthcare visits. New research shows significantly higher osteoarthritis incidence rates in military populations when compared to comparable age groups in the general population. Intense training for repetitive joint movement and traumatic joint injuries caused by multiple deployments make troops more prone to the joint disease. Current osteoarthritis treatments have limited effects on the prevention and progression of joint destruction. Most osteoarthritis patients rely on oral pain relievers to provide partial relief and physical therapy to strengthen the muscles around the injured joint. With increasing numbers of troops and general population suffering from this disease, a clear need exists for development of innovative drugs to treat and prevent osteoarthritis. We propose to develop a new and effective means for treating osteoarthritis. We will design and test a drug that affects the ability of a key hormone (parathyroid hormone) in the body to influence cartilage growth by making the hormone stimulate therapeutic, as opposed to disease-causing, intracellular signaling events. Successful completion of the proposed research will open a new avenue for the prevention and treatment of osteoarthritis, to the benefit of both military personnel and the civilian population.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jan 31, 2017
- Source ID
- W81XWH1610325
Entities
People
- Bin Wang
Organizations
- Thomas Jefferson University
- United States Army