Local Inhibition of HSP90 to Prevent Intimal Hyperplasia after Balloon Injury
Abstract
The proposed research is relevant to military and Veterans health because peripheral arterial disease and restenosis after balloon angioplasty to treat arterial blockages is a significant cause of disability and death in the military and Veteran population. Intimal hyperplasia is an important process in arterial restenosis development. These studies will (1) expand our understanding of the pathophysiology of intimal hyperplasia and the impact of HSP90 inhibitors on intimal hyperplasia and (2) establish the optimal method(s) of delivery of HSP90 inhibitors to decrease intimal hyperplasia. Thus, the findings from the proposed research are relevant to the Department of Defense s mission to decrease disability by providing safer, more effective care for military personnel and Veterans with peripheral arterial disease.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jan 31, 2017
- Source ID
- W81XWH1610762
Entities
People
- Kristopher Maier
Organizations
- State University of New York Upstate Medical University
- United States Army