A Novel Bandage Contact Lens Against Resistant Fungal Infections With Ocular Drug Delivery
Abstract
We propose to develop a novel, multifunctional, bioinspired antifungal therapeutic. This material would prevent the growth of fungal infections in wounds, in particular, those that may be resistant to common antifungal drugs. Our novel, bifunctional material is a composite, consisting of a drug reservoir core that delivers antifungal drugs at a constant rate, with outer surface layers made of inherently antimicrobial materials. We aim to implement this material as a crucial, proof-of-concept, bandage contact lens. Fungal eye infections usually result from traumatic eye injury and are particularly devastating, often resulting in blindness. Our device would have an immediate and great impact in preventing fungal infection in Warfighters with traumatic eye injuries. To achieve our goal, we will first synthesize the material, develop the device prototypes, and optimize device mechanical properties. We will also conduct in vitro testing of our device?s effectiveness against fungal pathogens. Next, we will tune the drug-delivery properties of our device so that optimal amounts of the antifungal compounds reach the wound. Finally, we will perform an in vivo study to test our device?s effectiveness against rabbit and murine fungal eye infections. Once proven, our material may be applied more broadly to different types of wound dressings useful to other Service members, Veterans, and the general population. This proposal addresses: Identification and evaluation of novel antifungals against resistant fungal infections, particularly topical therapies for wounds, surgical, and post-surgical therapies.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Aug 07, 2017
- Source ID
- W81XWH1710355
Entities
People
- Albert F. Yee
Organizations
- Naval Information Warfare Center Pacific
- United States Army