Epigenetic Pathways in Spinal Cord Injury
Abstract
Spinal cord injury (SCI) is a devastating neurological disorder that often results in permanent paralysis of young adults in the prime of their lives. Currently, there are no Food and Drug Administration-approved drugs to improve function after SCI. Thus, there is an urgent need to identify novel drugs that can improve outcome after SCI. It is generally believed that reducing inflammation shortly after trauma can limit tissue damage after injury. One means to reduce inflammation is to modulate the levels of epigenetic regulators. Important epigenetic modulators that play a role in inflammation include the Bromodomain and Extra-Terminal (BET) proteins. In this proposal, we will test novel compounds that inhibit BET proteins in animal models of SCI and assess their therapeutic efficacy.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Aug 07, 2017
- Source ID
- W81XWH1710460
Entities
People
- Jae Lee
Organizations
- United States Army
- University of Miami