Therapeutic Recovery of Immune and Lung Tissue Bioenergetic Homeostasis in Sepsis-Induced Immunosuppression
Abstract
Topic Area: Acute Lung Injury. This project aims to determine therapeutic potential of AMPK activators to improve outcome of sepsis. Our goal is to strengthen immunocompetence via AMPK-dependent improvement of mitochondrial bioenergetics. The proposal aims are designed to test the effects of metformin and Tideglusib on post-sepsis immunosuppression. We expect that these interventions in a preclinical model of polymicrobial sepsis will reduce a high risk of secondary lung infection, injury, and respiratory failure. The findings of this research are likely to impact understanding of mechanisms responsible for mitochondrial dysfunction during sepsis and lung injury and development of life-threatening immunosuppression. We also anticipate the subsequent development of new therapy for sepsis and post-septic complications.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Oct 29, 2018
- Source ID
- W81XWH1710577
Entities
People
- Jaroslaw W Zmijewski
Organizations
- United States Army
- University of Alabama at Birmingham