A Prolonged Damage Control Resuscitation Cocktail for Polytrauma
Abstract
This project addresses Focus Area 2: Develop next-generation resuscitation and stabilization methods for PFC [prolonged field care] and pDCR [prolonged damage control resuscitation], including novel or improved methods for resuscitation and stabilization of casualties with combined hemorrhagic shock and acute TBI [traumatic brain injury], with or without other concomitant injuries." The goal of this project is to optimize a new resuscitation cocktail for use during pDCR of the battlefield polytrauma casualty. The cocktail is made up of a combination of agents intended to increase blood pressure and simultaneously stop bleeding so that vital organs can be protected for long periods of time. This project seeks to optimize the delivery method of the cocktail, confirm its efficacy when there is coagulopathy present, and examine its safety and efficacy when given in combination with current tactical combat casualty care resuscitation. This project involves preclinical testing of the cocktail in the setting of TBI and free internal bleeding and will yield vital information regarding a new method for resuscitating the polytraumatized combat casualty over long periods of time.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Oct 29, 2018
- Source ID
- W81XWH1710651
Entities
People
- Nathan J White
Organizations
- United States Army
- University of Washington