Human Leukocyte Antigen in Gulf War Veterans: Association with Symptoms and Inflammatory Markers
Abstract
Gulf War Illness (GWI) has affected a large number of Veterans of the 1990-1991 Persian Gulf War. GWI symptoms are characterized by chronic, diffuse health problems of unknown etiology. Several lines of research suggest immune system involvement. To that end, we have recently published research highlighting involvement of Human Leukocyte Antigen (HLA) genes, which are known to regulate immune functioning. In this proposed epidemiological study, we will randomly recruit 500 participants from a list of 66,229 people who served from August 2, 1990 to April 11, 1991 (obtained from the Department of Defense) in order to evaluate the association of genotype, GWI symptomatology, and biomarkers of immune system dysfunction, inflammation, and autoimmunity in a large sample of Gulf War era Veterans with and without GWI. We expect that genetically susceptible individuals will be more likely to experience GWI symptoms and will demonstrate evidence of immune system disruption. The results of this study will contribute to better understanding the pathogenesis of GWI and can inform treatment approaches along the lines of immunogenetics for affected Veterans.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Oct 29, 2018
- Source ID
- W81XWH1710677
Entities
People
- Lisa James
Organizations
- United States Army
- University of Minnesota