Next-Generation Polymerized Hemoglobins for Use in Transfusion Medicine
Abstract
This application is in response to research area of interest 2a: Research and development of technologies to stop blood loss, resuscitate the casualty, and limit the immediate, short- and long-term deleterious consequences of severe hemorrhage. Potentially salvageable combat-related fatalities of military Service members due to rapid blood loss exceeds 50%. Prolonged field care with immediate restoration of blood volume and oxygen storage and transport capacity may be lifesaving, but blood transfusion is rarely available for point of injury, austere environment, or en route care casualties. Pre-evacuation standard of care relies on attempts at extrinsic hemostasis and resuscitation with plasma expander fluids. This approach has a range of adverse side effects. Thus, a red blood substitute with oxygen storage and transport properties that does not require cold preservation is likely to improve the outcome of battlefield casualties. We have demonstrated that large-sized blood substitutes improved survival of animals suffering from blood loss. Therefore, the goal of this work is to develop a safe and efficacious blood substitute for use by military Service members suffering from blood loss on the battlefield. The transport logistics of the blood substitute on the battlefield can be further enhanced by formulating the material in powder form that can be stored at ambient temperature without refrigeration for several years without loss of function and reconstituted at time of need with sterile water. In the civilian arena, these materials can be used at the site of terrorist attacks, natural disasters, and accidents when blood is not available.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Oct 29, 2018
- Source ID
- W81XWH1810059
Entities
People
- Andre Palmer
Organizations
- Ohio State University
- United States Army