Imaging Urothelial Integrity with Contrast-Sensitive Optical Coherence Tomography for Diagnosis of Interstitial Cystitis
Abstract
Interstitial cystitis (IC), also called painful bladder syndrome (PBS), is a chronic condition causing bladder pressure, bladder pain, and sometimes pelvic pain. Per varied definitions, around 3 and 8 million women in the U.S. may have IC/PBS. It may also be significantly underdiagnosed in males. The patients suffer not only from the disease itself, but also from poor quality of life due to associated depression, anxiety, and social and sexual dysfunction. The causes of BPS/IC, however, are unknown, which leads to uncertain diagnosis and treatment. The most popular idea is that urine waste invades into bladder wall due to the damage of the superficial layer of the bladder wall. Routine detection of this damage is very challenging as no technologies can visualize such damage objectively during a doctor visit. Optical coherence tomography (OCT), an optical imaging technology, could visualize the fine structures of tissue without invading into the tissue. We are going to develop new OCT technology to help urologists to objectively make diagnosis of IC/PBS.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Oct 29, 2018
- Source ID
- W81XWH1810104
Entities
People
- Hui Wang
Organizations
- Miami University
- United States Army