Metabolic Reprogramming of Myeloid-Derived Suppressor Cells in Post-Traumatic Osteoarthritis
Abstract
Post-traumatic osteoarthritis (PTOA) subsequent to acute joint injury accounts for a significant proportion of osteoarthritis (OA), with the rates of PTOA significantly higher in military populations compared to civilians. In PTOA of the knee, inflammation in the space surrounding the joint is caused by different kinds of white blood cells that release factors causing swelling and pain in the joint space. In obese individuals, there are increased amounts of inflammation in the blood stream that could recruit specific types of immune cells to the joint and cause tissue destruction. We propose to look into the nature of specific white blood cell populations that are known to be increased during obesity and determine if they can contribute to PTOA disease severity. We propose to look at this in both mice and humans to see if these specific white blood cells are amplified in the joint space and blood more in obese mice and humans compared to lean controls. To date, no studies have focused on these particular white blood cells in PTOA disease development and none during metabolic disease, such as obesity. We believe that this population of white blood cells is reprogrammed during obesity to degrade cartilage and/or bone, thus increasing PTOA disease severity. These are innovative studies since there is potentially new information to be gained through this award that could provide new therapeutic targets to manage the progression in PTOA, especially in populations where obesity exacerbates disease severity.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Oct 29, 2018
- Source ID
- W81XWH1810114
Entities
People
- Keith Kirkwood
Organizations
- United States Army
- University at Buffalo