Urinary Biomarkers of Tuberculosis: Potential for Diagnosis and Beyond
Abstract
Tuberculosis (TB) is the leading infectious cause of death worldwide. A major barrier to controlling the spread of this infection is the lack of reliable clinical tests that can be used for rapid diagnosis. Additionally, there is no good way to know if someone is responding to treatment. Biological markers were identified in urine that are capable of diagnosing pulmonary TB. This proposal aims to study these markers in groups of people suffering from active TB infection and compare them to urine from people who are exposed and at risk for developing disease. In addition, people who are being treated with antibiotics will be studied, to evaluate if these markers can be used to monitor whether treatment is working. If successful, these markers could dramatically improve the diagnosis of TB and help decrease the spread of drug-resistant strains through early detection of treatment failures.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Oct 29, 2018
- Source ID
- W81XWH1810133
Entities
People
- Flonza Isa
Organizations
- United States Army
- Weill Cornell Medicine