Hemodynamic Changes and Pancreatitis
Abstract
The proposed project relates to the Fiscal Year 2017 Peer Reviewed Medical Research Program topic area on pancreatitis. Acute pancreatitis is a painful acute inflammatory disease that can cause death in up to one-third of patients with severe disease. Its major etiology includes gallstones, smoking, alcohol, and drugs. However, the causes are not fully elucidated. In addition, the role of the lymphatic system is little understood in acute pancreatitis in particular and in the study of the pancreas in general. The development of simple and reproducible experimental models of acute pancreatitis that are relevant to human disease are urgently needed. This project addresses these critical problems with innovative ideas. First, the project will define a new etiology of acute pancreatitis and explore a previously undescribed mechanism in which pathological blood flow changes in the pancreas could induce acute pancreatitis. Second, it will examine the role of the pancreatic lymphatic system in acute pancreatitis, representing the first step toward understanding biology of the pancreatic lymphatic system. Third, a new and simple experimental model of acute pancreatitis, which can also be used for the study of the pancreatic lymphatic system, will be established. Addressing a new etiology and a new area of study, the project will significantly contribute to our understanding of the etiology and mechanism of acute pancreatitis and could lead to the identification of new risk factors as well as new therapeutic strategies for this disease.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Oct 29, 2018
- Source ID
- W81XWH1810184
Entities
People
- Yasuko Iwakiri
Organizations
- United States Army
- Yale University