Investigation of Metabolism in Hypertrophic Cardiomyopathy
Abstract
Topic Areas: This proposal addresses “Mitochondrial Disease” and “Women’s Heart Disease.” The goal of this proposal is to perform an in-depth study of metabolism in mouse hearts carrying mutations in their DNA that lead to thickening (hypertrophy) of heart muscle. Thickening of the heart muscle can occur from intense exercise in healthy individuals, but can also result from mutations in genes that code for heart proteins that are involved in heart contraction (hypertrophic cardiomyopathy). In this proposal, our goal is to use mouse models carrying mutations present in patients diagnosed with hypertrophic cardiomyopathy, to understand the metabolic basis of this disease. We propose metabolic studies at rest and following stimulation with an adrenaline-like drug (dobutamine) that increases cardiac work. We also will evaluate the effect of intense exercise induced by swimming on heart function and metabolism. Studies will be performed in male and female mice in order to improve translatability into humans. We anticipate that our study in two mouse models is the first step in development of personalized diagnostic tests and new therapies that prevent hypertrophic cardiomyopathy, which is the most frequent cardiac genetic disease worldwide and the most common cause of sudden cardiac death in athletes and young individuals.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Oct 29, 2018
- Source ID
- W81XWH1810316
Entities
People
- Maria Roselle Abraham
Organizations
- United States Army
- University of California, San Francisco