Defining Final Common Pathogenetic Pathway of Endoneurial Inflammation and Nerve Injury in Models of Immune Neuropathy
Abstract
The project relates to Guillain-Barré syndrome (GBS), which is a Fiscal Year 2017 (FY17) Peer Reviewed Medical Research Program (PRMRP) Topic Area. This research proposal addresses an FY17 PRMRP area of encouragement, i.e., “Research on the immune system cell types and molecular mechanisms responsible for the disease pathology of Guillain-Barré syndrome.” GBS is an inflammatory condition in which peripheral nerves are attacked. There are two major type of this disease; in one type the inflammatory cells attack insulating sheath of the nerve fiber whereas in the second type the inflammation attacks the neuronal process (axon) that conducts impulses. If the shared inflammatory components (cells and molecules) that attack insulating sheath or axon are identified in experimental models, then these inflammatory cells or molecules can be used as target for the development of new treatments applicable to the two major types of GBS. In this grant proposal, we plan to study and the role of inflammatory white blood cells called macrophages and specific proinflammatory receptors on these cells in different animal models of two major subtypes of GBS. We will also examine a treatment approach to reduce the inflammation in the nerves by targeting specific receptors on macrophage type cells. This treatment approach can be directly extended to GBS patients.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Oct 29, 2018
- Source ID
- W81XWH1810422
Entities
People
- Kazim Sheikh
Organizations
- United States Army
- University of Texas Health Science Center at Houston