Physiological Biomarkers of Resilience and Musculoskeletal Readiness
Abstract
Physiological resilience can be operationally defined as “the capacity to overcome stressors associated with military occupational duties to maintain performance and readiness”. Such stressors originate from volatile, uncertain, complex, and ambiguous (VUCA) battle conditions and involve the dynamic interplay of multiple biological systems. Given the high prevalence of musculoskeletal injury (MSI)-related disability resulting from strenuous physical training and occupational tasks, there is a need for physiological metrics that predict, discriminate, and monitor resilience against military operational stress. In this proposal, we examine biological signatures and countermeasures for physiological resilience using the latest advances in molecular, cellular, physiological, biomechanical, and mathematical science. This proposal directly complements US Army MOMRP and ARIEM Research Task Areas on physiological mechanisms of musculoskeletal injuries and physiological resilience. Specific Aims: The specific aims of this investigation are to: 1) Identify and validate a predictive algorithm for MSI during basic Army combat training (BCT); 2) Test the predictive efficacy of an enhanced biomarker matrix during the U.S. Naval Academy SEAL pre-selection screening program (Screener); and 3) Determine whether physical and physiological performance can be optimized during acute stress using non-invasive brain stimulation (NIBS). The aims of this project will be accomplished by addressing the following objectives.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jul 18, 2019
- Source ID
- W81XWH1810452
Entities
People
- Bradley C. Nindl
Organizations
- United States Army
- University of Pittsburgh