Acinetobacter baumannii, Type II Secretion, and Therapeutic Targeting
Abstract
Emerging infections caused by antibiotic-resistant Acinetobacter baumannii in hospitalized individuals pose important public health problems. Of particular concern are ventilator-associated pneumonia, urinary tract infections, and wound and bloodstream infections that may lead to sepsis. Extracellular protein secretion via the type II secretion system is important for Acinetobacter baumannii’s ability to survive in a mouse model of infection, in part due to the secretion of a protease that interferes with blood coagulation. The goals of this research are to determine how the type II secretion system and the secreted protease contribute to disease and to identify inhibitors of this secretion system that in later years may be developed into novel therapies to combat Acinetobacter baumannii infections.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Oct 29, 2018
- Source ID
- W81XWH1810587
Entities
People
- Maria Sandkvist
Organizations
- United States Army
- University of Michigan