Study of Immune-Based Biomarkers Using the Longitudinal CLIMB Dataset
Abstract
This proposal addresses the Focus Area Biological Correlates of Disease Activity and Progression in MS. What types of patients could it potentially help, and how? • This study can help all multiple sclerosis (MS) patients. • Specifically, we aim to identify blood biomarkers that will identify MS patients at high risk for relapses or disability worsening. This will allow doctors to intervene with stronger treatments or different management or monitoring strategies. • We will also identify predictive biomarkers of response to specific MS treatments. This will allow doctors to better choose a treatment or identify early if a treatment is not working. • We will also develop biomarkers and predictive models of long-term outcomes that can help to identify patients at higher risk of severe outcomes, and intervene appropriately. What are the potential clinical applications, benefits, and risks? • The potential clinical applications include biomarkers or predictive models for treatment response and short-term and long-term disease outcome. • These will identify patients who would benefit from more aggressive or different treatment strategies. • We may also identify new ways of treating MS. • The risks are that models are inaccurate. We are using large groups of patients to create these models, and we will cross-validate within the datasets. Additional datasets may be used to further prove these models. What is the projected time it may take to achieve a patient-related outcome? • We are using previously stored blood samples and patient data, and we have a highly efficient and collaborative team of investigators, who have worked together for many years. • Therefore, we will have our first patient-related results in 15 months after the study start. • We will have all final results of this study within 36 months.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Oct 29, 2018
- Source ID
- W81XWH1810648
Entities
People
- Tanuja Chitnis
Organizations
- United States Army