A Translatable Peptide Combined with Exercise to Restore Function After Spinal Cord Injury
Abstract
Significant accomplishments have been made in the development of new treatments for spinal cord injury (SCI) from basic science research through clinical application. However, the far more challenging goal of repairing the progressively damaged spinal cord to restore function is still largely under-achieved. The ultimate goal of this proposal is to promote maximal recovery of both walking and bladder functions after SCI using a combinatorial strategy that is easily delivered and has a low risk of further injury or side effects. We will use (1) a novel peptide (a small molecule that can be easily delivered by subcutaneous injection) to decrease inflammation combined with (2) an exercise approach in an animal model to achieve the best functional recovery after SCI. Therefore, the success of this proposal could translate to clinical applications in the near future.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Oct 29, 2018
- Source ID
- W81XWH1810695
Entities
People
- Ching-yi Lin
Organizations
- Cleveland Clinic
- United States Army