Identification of Novel Genetic Causes of Lung Cancer by Sequencing the Germline Exome of Never-Smoker Young Lung Cancer Patients
Abstract
Treatment efficacy and survival has been constantly improving over the past several decades for children and for adults over 40 years of age. For the young adult population, however, especially those between 20 and 40 years of age, no progress has been made. This is a population highly represented in the military services. Identification of genetic factors contributing to the development of cancer may help to identify individuals at high risk and thus provide rational strategy for prevention and through understanding the underlying biology it can also help to devise novel therapeutic strategies. Earlier efforts to identify genetic factors contributing to lung cancer probably missed several relevant mutations since they have been limited in many ways that we are aiming to overcome in this proposal. We will sequence the germline DNA of lung cancer patients that are under 35 years of age, who never smoked, and had no apparent exposure to toxic chemicals. In such a population, genetic factors will play a more prominent role than in an older population more affected by environmental factors; therefore, those genetic factors could be identified more easily.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Oct 29, 2018
- Source ID
- W81XWH1810751
Entities
People
- Zoltán Szállási
Organizations
- United States Army