3D-Fabricated Nitric Oxide-Releasing Matrix as an Antimicrobial Dressing
Abstract
Wounded military personnel, especially involving extremity wounds, face the high infection rate during the initial hospitalization. Immediate wound care is critical to avoid infections, which can lead to prolonged hospitalization, increased morbidity, and slow rehabilitation. Appropriate wound dressings or the application of bandages at the time of injury is the first line of defense to prevent wound infection. Broad-spectrum antibiotics are administered as a prophylactic measure to prevent nosocomial infections during surgical procedures, increasing the risk of developing antimicrobial resistance. These microorganisms are strongly associated with hospital-acquired infections contributing to the persistence of debilitating wound infections in both military and non-military patients. This application specifically addresses the Fiscal Year 2018 Peer Reviewed Medical Research Program Topic Area: Antimicrobial Resistance, and the Encouragement Area: Development of novel and/or innovative interventions, diagnostics, and treatment for multidrug-resistant pathogens, especially those that can be used in austere settings. The grant application entitled ?3D-Fabricated Nitric Oxide Releasing Matrix as an Antimicrobial Dressing? focuses on the development of novel therapeutic strategies capable of not only targeting the infectious burden but also limiting the inflammatory cascade that ultimately leads to septic physiologic derangements. In this project, we propose to develop nitric oxide (NO) releasing matrix, NOmatrix, as an antimicrobial dressing to prevent wound infections and combat antimicrobial resistance. The proposed NOmatrix as a dressing not only is effective to treat infected wounds but also is convenient to store, carry, and apply, which allows on-site emergency treatment of wounds. NOmatrix, upon contact with moisture/water, will only release NO at the site of injury. The sustained release of NO from NOmatrix can enhance the therapeutic efficacy of NO and prevent the injury from microbial infections. Since the polymers used in this study are already in clinical use, it can be rapidly translated to the human clinical trials. The 3D-fabricated NOmatrix as a dressing, because of its simple and inexpensive fabrication method, will be a major advancement in the rapid and efficient treatment of antimicrobial-resistant infections and nosocomial infections.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Mar 05, 2019
- Source ID
- W81XWH1910091XX0
Entities
People
- Crystal S Shin
Organizations
- Baylor College of Medicine
- United States Army