Angioprevention of Stomach Cancer
Abstract
This proposed research will address fiscal year 2018 Peer Reviewed Cancer Research Program Topic Area: Stomach Cancer. Because recent reports demonstrate VEGF-A induced angiogenesis or new blood vessel formation in pre-neoplastic gastric lesions, we hypothesize that targeting angiogenesis in these lesions might prevent gastric cancer. As we have identified a novel, inexpensive, and safe edible plant-based water soluble small molecule, chebulagic acid (CA) with novel anti-VEGF-A actions and good bio-availability, we will therefore investigate the effects of treatment with CA on the initiation and progression of pre-neoplastic gastric lesions to malignant gastric tumors in a well-established preclinical mouse model simulating the lesions observed in human patients suffering from intestinal type of gastric cancer, the most common type of gastric cancer seen in the world. Because about 65% of gastric cancer patients present with metastasis and they ultimately die within one year of diagnosis, our study may identify a new and an effective therapeutic approach to target the pre-neoplastic stages of the disease with the possibilities for prevention of gastric cancer in patients, including active duty Service members, Veterans, and their family members diagnosed harboring these lesions by upper GI endoscopy, biopsy, and histopathology.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Nov 19, 2019
- Source ID
- W81XWH1910233
Entities
People
- Sujit Basu
Organizations
- Ohio State University
- United States Army