Effects of Passive Immunization on Immunogenicity of Filovirus Vaccines
Abstract
This proposal directly addresses the Topic Area Vaccine Development for Infectious Diseases, Area of Interest “Evaluation of passive immunization strategies to use in conjunction with emerging infectious disease vaccinations.” The overall research idea of this proposal is to develop a treatment regimen against Ebola virus that will protect someone from infection immediately and for a long time. Right now, there are drugs that look promising for their ability to protect someone from Ebola virus infection, but the drugs only protect over a short period of time. On the other hand, there are Ebola virus vaccines that can protect someone for a long time after vaccination, but it takes days to weeks before the vaccine can protect from infection. What is needed is a combination of these drugs and vaccines, so that an individual can be protected from Ebola virus immediately, and also for a long time. This would be optimal for people that are in an Ebola virus outbreak, or for doctors or Soldiers who are sent to be in the middle of an outbreak to control the infection and treat the patients. In this proposal, different combinations of Ebola virus drugs and vaccines will be tested in mice, and the best combination that results in high levels of drugs in the mice short term and good immune responses induced by the vaccines long term will be determined. This will result in a drug and vaccine combination regimen that will provide both immediate and long-lasting protection against Ebola virus. Since Ebola virus is very dangerous, killing between 40%-90% of infected patients, and is a virus that is becoming more common, this proposal addresses an important need in protecting people from infection.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Nov 19, 2019
- Source ID
- W81XWH1910433
Entities
People
- Steven Bradfute
Organizations
- Health Sciences Center, University of New Mexico
- United States Army