Effect of NMN Supplementation on Metabolic and Muscle Function in Prediabetes
Abstract
This proposal addresses the Fiscal Year 2018 Peer Reviewed Medical Research Program Topic Area “Diabetes” and relates to a Topic Area of Encouragement “Identification and/or evaluation of interventions to reduce the development of diabetes among individuals meeting the clinical criteria for prediabetes.” Prediabetes (defined as having a fasting blood glucose concentration of 100-125 mg/dl, a blood glucose of 140-199 mg/dl 2 hours after a ingesting a 75-gram glucose drink, or a hemoglobin A1C value [a measure of sugar red blood cell blood sugar exposure] of 5.7%-6.4%) has become a major public health problem in the general population and military Veterans in the United States because of their high prevalence, causal relationship with serious medical complications (including type 2 diabetes, fatty liver disease, abnormal blood lipids, and coronary heart disease), adverse effects on quality of life, and economic consequences caused by increased healthcare costs. The data from a series of studies we conducted previously in rodents demonstrated that nicotinamide mononucleotide (NMN), a naturally occurring nutrient found in natural food sources, had impressive beneficial metabolic, skeletal muscle energy metabolism, and immune system effects, without any evidence of side effects. We hypothesize that NMN supplementation can also improve metabolic function, skeletal muscle health, and inflammation in people. In an effort to test this hypothesis and to determine whether our findings in rodents apply to people, we will conduct 12-week, randomized, placebo-controlled trial in people who have prediabetes to determine whether NMN has beneficial effects on metabolic health, muscle energy metabolism, and inflammation. Specifically, we will evaluate the efficacy of NMN supplementation (250/mg/day) on: (1) body composition (body fat mass and lean body mass, intra-abdominal fat volume, and liver fat content); (2) insulin sensitivity in adipose tissue (ability of insulin to suppress fat breakdown), liver (ability of insulin to suppress liver glucose production) and skeletal muscle (ability of insulin to stimulate glucose disposal from the bloodstream); (3) the ability of the pancreas to produce and secrete insulin; (4) skeletal muscle ability to produce energy; (5) markers of inflammation in the bloodstream and in fat tissue; and (6) cellular factors in fat and muscle tissue that could be involved in impaired metabolic function and energy production. The results obtained from the studies conducted in this proposal will provide important insights into the potential of using NMN as a new therapy to improve metabolic function, muscle health, and inflammation in people who have prediabetes. This project has considerable military relevance because prediabetes and T2D are more common among military Veterans than the general population. Accordingly, the results from the studies proposed in this application could have a considerable impact on the clinical management and health of our military Veterans and active personnel, as well as the general population.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Nov 19, 2019
- Source ID
- W81XWH1910504
Entities
People
- Samuel Klein
Organizations
- United States Army
- Washington University in St. Louis