The Pathogenesis and Therapy of Chromophobe Renal Cell Carcinoma: A Single-Cell RNA Sequencing Approach
Abstract
Chromophobe renal cell carcinoma (RCC), the third most common subtype of RCC, represents ~5% of all RCC. The prognosis for patients with metastatic Chromophobe RCC (ChRCC) is estimated to be less favorable than for metastatic clear cell RCC. Single-cell RNA-Seq (scRNA-Seq) is a relatively new method for investigation of the RNA molecules made by each individual cell within a tumor, including not only the tumor cells but also immune cells and blood vessels. Single cell ATAC-Seq (scATAC-Seq) is used to investigate which regions of the DNA are most active. We will use these state-of-the-art techniques to study ChRCC. Our central hypothesis is that profiling these tumors on a single cell basis will lead to a better understanding of what is driving the growth of ChRCC and thereby lead to new, highly effective treatments.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Nov 19, 2019
- Source ID
- W81XWH1910550
Entities
People
- Elizabeth P Henske
Organizations
- Brigham and Women's Hospital
- United States Army