REV-ERB Antagonists for Treatment of Muscle Injuries
Abstract
Muscle injuries, both overuse and traumatic, are common in military personnel. This research focuses on development of novel pharmacological therapies to accelerate muscle regeneration following these types of injuries and thus would have a significant impact on improving military performance and readiness. We developed synthetic REV-ERB antagonists and demonstrated that they are effective in acceleration of muscle healing after injury. Here, we focus on developing optimized REV-ERB antagonists so that we may develop effective drugs for treatment of muscle injury in humans.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Nov 19, 2019
- Source ID
- W81XWH1910633
Entities
People
- Bahaa El-gendy
Organizations
- United States Army
- University of Health Sciences and Pharmacy in St. Louis