Acute Burn ResUscitation Prospective Multicenter Observational Trial 2 (ABRUPT2)
Abstract
Any injury leads to local swelling. A massive burn leads to the most swelling known. In essence, fluid inside the burn patient’s blood vessels leaks out so fast that people die if fluids are not rapidly replaced. In order to survive a major burn, patients must have fluids replaced by vein at a very fast rate. If too little fluid is provided, patients may develop kidney failure or even die. If too much fluid is given, then patients may develop complications from extra swelling that leads to damage to limbs and organs. The old teaching was that fluids containing only water and salt (sodium chloride) should be provided. Studies suggest, however, that salt solutions may lead to providing too much fluid. Albumin is the most abundant protein in our blood and its main role is to keep water inside the blood vessels. In theory, providing albumin should reduce the amount of fluid required for any resuscitation. The problem is that some albumin leaks with any injury. Recent data, however, suggests that adding albumin has to potential to reduce fluids required for patients with massive burns. We have been performing a study, funded by the Department of Defense, that looks at the fluid resuscitation practices of burn centers of North America. The study has collected data as to the use of salt water or albumin for the treatment of burn patients in the first 48 hours after injury. The goal was to use these data to design a trial that prospectively and randomly evaluates the use of the salt water or an albumin solution. This proposal will take the next step by using the data obtained from the previous study and perform the definitive prospective, randomized, multicenter trial to demonstrate the value of using albumin to reduce acute burn resuscitation.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Nov 19, 2019
- Source ID
- W81XWH1910664
Entities
People
- David G Greenhalgh
Organizations
- United States Army
- University of California, Davis