Regulation of Energy Balance by a Gut-Brain Axis Mediated by SCFAs and FFA2/3 in the Brain
Abstract
Type 2 diabetes (T2D) is now recognized as a serious global health problem. The gut microbiota has recently been identified to contribute to obesity, insulin resistance, and the subsequent development of T2D, but how it modulates metabolism is unclear. We propose to determine if gut microbiota-derived nutrient metabolites, short chain fatty acids (SCFAs), act on the central nervous system (CNS) to regulate body weight balance. Moreover, we will assess if dysfunction of this central pathway contributes to the development of obesity, and ultimately if enhancement of its functions can treat obesity and prevent diabetes.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Mar 10, 2021
- Source ID
- W81XWH2010075
Entities
People
- Brian T Layden
Organizations
- United States Army
- University of Illinois at Chicago