Authentic Mouse Model of PRSS1-Related Hereditary Pancreatitis
Abstract
Topic Area: Pancreatitis Chronic pancreatitis is a relapsing-recurring inflammatory disorder of the pancreas characterized by destruction of pancreatic acinar and islet cells, inflammatory cell infiltration, fibrosis, and calcifications within the pancreatic ducts. These morphological changes typically result in the clinical symptoms/diseases of malabsorption, abdominal pain, and diabetes mellitus. Chronic pancreatitis increases the risk for pancreatic cancer. Owing to the unavailability of specific therapy and the persistent and often severe symptoms, the cost of lifelong supporting care for Veterans and active military personnel presents a significant financial and logistical challenge for the military healthcare system. Animal models that mimic features of human chronic pancreatitis are essential for understanding the disease mechanism and for the development of new therapeutic and preventive approaches. The aim of the present proposal is to generate and characterize a preclinical mouse model of hereditary pancreatitis. This new model will carry a mutation that is frequently found in patients with hereditary pancreatitis. These mice are expected to develop pancreatitis spontaneously or show increased sensitivity to experimentally elicited pancreatitis. The proposed experiments will generate much-needed insight into the pathological mechanisms of chronic pancreatitis and open up new avenues for therapy and prevention.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Mar 10, 2021
- Source ID
- W81XWH2010134
Entities
People
- Zsanett Jancso
Organizations
- United States Army
- University of California, Los Angeles