Targeting Oxidative Stress to Prevent Intervertebral Disc Degeneration
Abstract
This proposal addresses the Fiscal Year 2019 Peer Reviewed Medical Research Program Topic Area Musculoskeletal Disorders with an emphasis on the contribution of Mitochondrial Disease to intervertebral disc (IVD) degeneration (IDD), which occurs after disc injuries sustained by Soldiers in combat and non-combat scenarios. Intervertebral disc degeneration is clinically considered as a significant source of low back pain, which is one of the common problems in our society and has ranked the second most common medical symptom leading to physician visits, hospitalization, and utilization of other healthcare services. Although the disc degeneration can be induced by a variety of factors such as genetic factors, limited nutrient supply, and mechanical stimulation, recent studies have clearly demonstrated that oxidative stress contributes to progression of disc degeneration. In this project, we will test a novel strategy to reduce oxidative stress by preventing damage to mitochondria in IVD cells. The development of a practical and advanced method to prevent disability from IDD is beneficial for military health as well as the civilian population. The acquisition of knowledge, information, and technologies from this proposal will lay the groundwork for more extensive studies in large animal models, a prerequisite for clinical trials.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Mar 10, 2021
- Source ID
- W81XWH2010152
Entities
People
- Dong Rim Seol
Organizations
- United States Army
- University of Iowa