Detection and Diagnosis of Lung Cancer Using High-Resolution Endoscopic Optical Imaging
Abstract
Lung cancer diagnosis heavily relies on the analysis of the biopsy samples collected from lesions in the lungs. Biopsy acquisition in the lungs is, however, highly error-prone due to missing lesions or sampling non-tumor part of lesions. There is a need for tools that can visualize lesions to guide biopsy collection. In this project, we will develop a miniature imaging-biopsy catheter that can access small airways in the lung periphery and visualize lesions in high-resolution for subsequent biopsy acquisition. This is expected to improve screening and early detection of lung cancer through acquisition of tissues with a higher chance of containing tumor cells. This technology can greatly benefit patients suffering from lung cancer through early and accurate detection, diagnosis, and timely interventions to improve morbidity and mortality. The ability of the proposed catheter to capture high-resolution images of lesions in the lungs will also have research benefits through providing the visual structural changes in the airway structures associated with the development of cancer. This technology is particularly important for military personnel who are at a higher risk of lung cancer due to several factors, including higher smoking rates and exposure to a wide range of agents linked to lung cancer such as asbestos, radon, and chromium, among others.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Mar 10, 2021
- Source ID
- W81XWH2010300
Entities
People
- Hamid Pahlevaninezhad
Organizations
- Massachusetts General Hospital
- United States Army