Lactoferrin-Based Combination Therapies to Prevent Biofilm Implant-Related Infection
Abstract
Service members on the front lines of battle often suffer from traumatic injuries, including open fractures. In later years, as Service members become Veterans, they may require additional medical care that could include prostheses such as total joint replacements. In both cases, hardware may be used to repair damaged tissue. One of the risks with hardware in the body is the formation of bacterial biofilms. Biofilms are complex communities of bacteria that are particularly tolerant to traditional antibiotic therapies. These communities may contaminate a wound site at the point of injury or develop following elective surgery, and cause hardware-associated infection. This international collaborative study is designed to assess the ability of two products — an antibiofilm lavage solution to irrigate biofilm-contaminated wounds and a local-release antibiofilm bone cement to eliminate biofilms near hardware using high doses of synergistic antimicrobials to treat and prevent biofilm hardware-associated infections that affect Service members and Veterans.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Mar 10, 2021
- Source ID
- W81XWH2010370
Entities
People
- Jillian Cornish
Organizations
- United States Army
- University of Auckland