The R&D of New Antifungals
Abstract
Fungal infections have dramatically increased during the last decade and new treatment strategies are needed. This proposal focuses on developing new compounds targeting the fungal but not the mammalian sphingolipid pathway. This will be performed by screening different compound synthetic libraries to identify compounds that would inhibit the growth of fungi afflicting military and non-military personnel, such as yeasts and molds. Once the hit compound(s) will be identified, we will test for their toxicity versus mammalian cells and proper medicinal chemistry will commence to improve their activity, decrease their toxicity and improve their pharmacokinetics properties (e.g., oral absorption, plasma half-life). Lead compound(s) will be used to treat animals affected by these fungi, and their efficacy will be compared to the standard of care. Finally, a lead compound(s) will advance by filing an Investigational New Drug (IND) with the Food and Drug Administration (FDA).
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Mar 10, 2021
- Source ID
- W81XWH2010390
Entities
People
- Maurizio Del Poeta
Organizations
- United States Army