OMX-CV, A Novel Oxygen Delivery Biotherapeutic for Treatment of Hemorrhagic Shock in the Battlefield
Abstract
Massive bleeding on the battlefield is the number one cause of potentially preventable combat deaths prior to arrival at a medical treatment facility. Even though improved approaches to managing these critically ill patients has shifted to include practices designed to limit the transfusion of blood products, 330,000 units of blood products had been used in the battlefield in 2014 alone. Importantly, the ability to safely and efficiently deliver blood products to the combat setting requires a large investment of resources and is associated with several challenges including risk of adverse reactions and infections. Here, we propose to test the efficacy of a novel oxygen delivery molecule to support tissue oxygen levels and minimize the need for blood transfusions in the combat setting. Unlike prior efforts at developing Hemoglobin-based oxygen carriers (HBOCs) that were prevented from further development by the Food and Drug Administration (FDA) due to safety concerns, the OMX-CV therapeutic developed by Omniox, Inc. under investigation here is engineered to minimize reactivity with nitric oxide and thus produce minimal vascular side effects. We present extensive preclinical data from small and large animal models of hypoxia, stroke, and hemorrhage indicating the safety and efficacy of these compounds in the critical care setting. We propose to further develop this therapy specifically for the treatment of hemorrhage using large animal models that faithfully recapitulate human physiology. Additionally, we will develop versions of OMXCV that are easily administered in the combat setting and ensure that it is similarly safe and effective. The successful development of this therapy has the potential to dramatically decrease the need for blood transfusions and decrease mortality rates during combat.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Mar 10, 2021
- Source ID
- W81XWH2010929
Entities
People
- Emin Maltepe
Organizations
- United States Army
- University of California, San Francisco