Fibrin Degradation Products as Novel Drivers of Coagulopathy and Blood Failure After Trauma
Abstract
This Discovery Award project proposal seeks to discover the role of fibrin degradation products (FDPs) in the mechanism of the coagulopathy of trauma. FDPs are increased significantly after trauma, but have been largely dismissed as being only correlates of injury having no direct role in bleeding, and therefore unimportant. However, abundant evidence exists from basic investigations that FDPs are capable of contributing directly to pathological coagulation mechanisms that promote bleeding. Our untested theory is that FDPs directly exacerbate the coagulopathy of trauma by promoting anticoagulation and hyperfibrinolysis. Discovery of the role of FDPs in the mechanism of the coagulopathy of trauma will enable development of novel diagnostics, such as point-of-care FDP detection assays and new therapeutics including FDP-directed monoclonal blocking antibodies and antifibrinolytic agents. This project is innovative because it will discover an unknown aspect of the coagulopathy of trauma, which will lay the groundwork for future development of novel FDP-specific diagnostics and therapeutics.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Dec 05, 2021
- Source ID
- W81XWH2110151
Entities
People
- Nathan J White
Organizations
- United States Army
- University of Washington